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David Nochlin, M.D.
Area of Specialty: Neuropathology
Professional Appointments: Attending Neuropathologist NJ Neuroscience
Institute JFK, Edison , NJ
Academic Appointments: Associate Professor, Department of Neuroscience (In process) Seton Hall University School of Graduate Medical Education, South Orange, NJ; Research Assistant Professor, Assistant Professor, Senior Lecturer University of Washington School of Medicine, 1988-2003.
Graduate Education: Rotating Internship, West Jersey Hospital . Camden, NJ, 1973-1974; Neurology Residency, Kingsbrook Jewish Medical Center and S.U.N.Y. Downstate Medical Center - Kings County Hospital Center, Brooklyn, NY, 1974-1977; Anatomic Pathology - Neuropathology Fellowship. Medical College of Virginia – Virginia Commonwealth University, Richmond, VA, 1977-1980; Senior Staff Fellow, Laboratory of Neurosciences, National Institute on Aging, N.I.H., Bethesda, MD, 1984-1986; Senior Neuropathology Fellow, Alzheimer's Disease Research Center. University of Washington School of Medicine , Seattle, WA, 1986-1988.
Medical School: Faculty of Medicine, National Autonomous University of Mexico (U.N.A.M.), Ciudad Universitaria, México, D.F., MÉXICO (1972)
Specialty Board Certification: American Board of Pathology: Neuropathology, 1980
Research Interests: Degenerative diseases of the nervous system
Professional Memberships: American Association of Neuropathologists, International Society of Neuropathology, U.S.-Canadian Academy of Pathology, American Association for the Advancement of Science, American Registry of Pathology, New York Academy of Sciences, Society for Neuroscience, Washington State Medical Association, American College of Physicians, American Academy of Neurology, American Medical Association.
Honors and Awards: Weil Award, Honorable Mention, Sixty-fifth Annual Meeting, American Association of Neuropathologists, 1989; Life member of the National Registry of Who'sWho (184802), 2002; Marquis Who'sWho®. Who'sWho in Medicine and Healthcare, 2002-present; Marquis Who'sWho®. Who'sWho in Science and Engineering, 2002-present; Marquis Who'sWho®. Who'sWho in America , 2003-present; International Health Professional of the Year, International Biographical Centre, Cambridge , England . 2003-present; International Scientist of the Year, International Biographical Centre, Cambridge , England . 2003-present.
Professional Experience: Private Practice, México, D.F ., MÉXICO, 1972-1973 Cl nical Assistant Professor of Pathology, New York Medical College and Westchester County Medical Center, Valhalla, NY 1980-1982 and 1983-1984; Attending Neuropathologist, Neurosurgery Service, General Hospital, National Medical Center, Mexican Institute of Social Security (IMSS), México, DF , MÉXICO , 1982-1983; University of Washington School of Medicine Affiliated Hospitals, Seattle, WA, 1988-2003: Attending Neuropathologist: Autopsy and Neuropathology Core D (Alzheimer's Disease Research Center), Department of Pathology, Neuropathology Laboratory: Harborview Medical Center and University of Washington Medical Center, Consultant Neuropathologist, Children's Hospital and Regional Medical Center, and Veterans Affairs Medical Center; Interim Director, Autopsy and Neuropathology Core D, Alzheimer's Disease Research Center, 1996-1998.
Representative Publications:
Wijsman EM, Daw EW, Yu X, Steinbart EJ, Nochlin D, Bird TD, Schellenberg GD. APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation. Am J Med Genet (Neuropsychiatric Genetics) 2005;132B:14-20. Epub 2004 Sep 23
Tsuang D, Simpson KL, Li G, Barnhart RL, Edland SD, Bowen J, McCormick W, Teri L, Nochlin D, Larson EB, Thompson ML, Leverenz JB. Evaluation of Selection Bias in an Incident-Based Dementia Autopsy Case Series. Alzheimer Dis Assoc Disord 2004; 19:67-73
Riekse RG, Leverenz JB, McCormick W, Bowen JD, Teri L, Nochlin D, Simpson K, Eugenio C, Larson EB, Tsuang D. Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study J Am Geriatr Soc 2004; 52:1442-1448
Wijsman EM, Daw EW, Yu CE, Payami H, Steinbart EJ, Nochlin D, Conlon EM, Bird TD, Schellenberg GD. Evidence for a novel late-onset Alzheimer's disease locus on chromosome 19p13.2. Am J Hum Genet 2004; 75:398-409. Epub 2004 Jul 08
Chen D-H, Brkanac Z, Verlinde CLMJ, Tan X-J, Bylenok L, Nochlin D, Matsushita M, Lipe H, Wolff J, Fernandez M, Cimino P J, Bird TD, Raskind W. Missense mutations in the regulatory domain of PKC?: A new mechanism for dominant nonepisodic Cerebellar Ataxia. Am J Hum Genet 2003;72:839-849 . Epub 2003 Mar 17
Brkanac Z, Bylenok L, Fernandez M, Matsushita M, Lipe H, Wolff J, Nochlin D, Raskind WH, Bird TD. A new dominant spinocerebellar ataxia is linked to chromosome 19q13.4-qter. Arch Neurol 2002;59:1291-1295
Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland SD, Nochlin D, DiGiacomo L, Bowen JD, McCormick WC, Teri L, Raskind MA, Kukull WA, Larson EB. Clinical and neuropathological characteristics of hippocampal sclerosis: A community-based study. Arch Neurol 2002;59:1099-106
Husseman JW, Hallows JL, Bregman DB, Leverenz JB, Nochlin D, Jin L-W, and Vincent I. Hyperphosphorylation of RNA Polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer's disease. J Neuropathol Exp Neurol 2001; 60:1219-1232
Piccardo P, Liepnieks JJ, William A, Dlouhy SR, Farlow MR, Young K, Nochlin D, Bird TD, Nixon RR, Ball MJ, DeCarli C, Bugiani O, Tagliavini F, Benson MD, Ghetti B. Prion proteins with different conformations accumulate in Gerstmann-Sträussler-Scheinker disease caused by A117V and F198S mutations. Am J Pathol 2001;158:2201-2207
Tomashevski A, Husseman J, Jin L-W, Nochlin D, Vincent I. Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration. J Alzheimers Dis 2001;3:195-207
Poorkaj P, Grossman M, Steinbart E, Payami H, Sadovnick A, Nochlin D, Tabira T, Trojanowski JQ, Borson S, Galasko D, Reich S, Quinn B, Schellenberg G, Bird T. Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch Neurol 2001; 58: 383-387
Vincent I, Bu B, Hudson K, Husseman J, Nochlin D, Jin L. Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease. Neuroscience 2001;105:639-50.
Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T and the Members of the FAD Pathology Study Group: Arango J, Bird T, Van Broeckhoven C, Brooks W, Brown R, Cairns N, Cras P, Ellison D, Haltia M, Ii K, Jorgensen A, Krill J, Lantos P, Lippa C, Martins R, Nochlin D, Pollen D, Rosenberg C, Rossor M and Tabira T. Amyloid angiopathy and variability in A b deposition is determined by mutation position in PS-1 linked Alzheimer's disease. Am J Pathol 2001;158:2165-2175
Ding XL, Husseman J, Tomashevski A, Nochlin D, Jin LW, Vincent I . The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Am J Pathol 2000;157:1983-1990
Husseman JW, Nochlin D and Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases . Neurobiol Aging 2000; 21:815-828
Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Dole K, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, L évesque L, Fraser PE, Andreadis A and Nixon RA. Brain expression of presenilins in sporadic and early onset, familial Alzheimer's disease. Molecular Medicine Mol Med 2000;6:878-891
Lippa CF, Swearer JM, Kane MA, Nochlin D, Bird TD, Ghetti B, Nee LE, Pollen DA, Drachman DA. Familial Alzheimer's disease: Site of mutation influences clinical phenotype. Ann Neurol 2000; 48:376-379
Armstrong RA, Nochlin D and Bird TD. . Neuropathological heterogeneity in Alzheimer's disease: A study of 80 cases using principal components analysis. Neuropathology 2000;20:31-37
Daw EW, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM. The number and contribution of trait loci in age-of-onset of late-onset Alzheimer's disease. Am J Hum Genetics 2000;66:196-204
Nochlin D, Shaw C-M, Campbell LA , and Kuo C-C. Failure to detect Chlamydia pneumpniae in brain tissues of Alzheimer's disease. Neurology 1999;53:1888
Gomez-Isla T, Growdon WB, McNamara MJ, Nochlin D, Bird TD, Arango JC, Lopera F, Kosik K, Lantos PL, Cairnes NJ and Hyman BT. The impact of different presenilin 1 and presenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain. Brain 1999;122:1709-1719.
D'Souza I, Poorkaj P, Hong M, Nochlin D, Lee VM-Y, Bird TD, Schellenberg GD. Missense and silent tau gene mutations cause fronto temporal dementia with parkinsonism - chromosome 17 type by affecting alternative splicing. Proc Natl Acad Sci 1999;96:5598-5603 .
Lim A, Tsuang D, Kukull W, Nochlin D, Leverenz J, McCormick W, Bowen J, Teri L, Thompson J, Peskind E, Raskind M, Larson E. Clinico-Neuropathological correlation of Alzheimer's disease in a comunity-based case series. J Am Geriatr Soc 1999;47:564-569.
Bird TD, Nochlin D, Poorkaj P, Cherrier M, Kaye J, Payami H, Peskind E, Lampe TH, Nemens E, Vonsattel JP, Schellenberg GD. A clinical pathological comparison of three families with fronto-temporal dementia and identical mutations in the tau gene (P301L). Brain 1999;122:741-756.
Lippa CF, Schmidt ML, Nee LE, Bird T, Nochlin D, Hulette C, Mori H, Lee VM-Y and Trojanowski JQ. AMY Plaques in familial AD. Comparison with sporadic Alzheimer's disease. Neurology 2000:54:100-104 Nochlin D, Bird TD, Nemens EJ, Ball MJ and Sumi SM. Amyloid angiopathy in a Volga German family with Alzheimer's disease and a PS2 mutation (N 141 I). Ann Neurol 1998;43:131-135.
Armstrong RA, Wade KM, Nochlin D and Bird TD. Is neuropathological heterogeneity in Alzheimer's disease related to apolipoprotein genotype? Alzheimer's Rep 1998;1:217-221.
Lippa CF, Fujiwara H, Mann DMA, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee V M-Y, Iwatsubo T, Trojanowski JQ. Lewy bodies contain altered a-synuclein in brains of many familial Alzheimer's disease patients with mutations in presinilin and amyloid precursor protein genes. Am J Pathol 1998;153:1365-1370.
Sarnat HB, Nochlin D, Born DE. Neuronal nuclear antigen (NeuN): A marker of neuronal maturation in the early human fetal nervous system. Brain Development 1998;20:88-94.