Pupillometry uses harmless infra-red illumination of the eyes to measure the size of the pupils under different lighting conditions. Measuring the pupil and its reaction to different types of stimuli allow us to gain new insight into the basic anatomy of the visual system. We are moving this knowledge from the laboratory into the clinical realm and using pupillary reactions to diagnose and follow patients with a variety of lesions involving the eye and the central nervous system. Patients with disorders involving the optic nerves, optic chiasm and midbrain in particular have characteristic changes in pupil responses.
PUPIL RELATED PAPERS AND PUBLISHED ABSTRACTS
ROSENBERG M: Miotic Adie's Pupils. J Clin Neuro-ophthalmol 9(1):43-45, 1989.
ROSENBERG ML, Oliva A: The use of crossed polarized filters in the measurement of the relative afferent pupillary defect. Am J Ophthalmol 110:62-65, 1990.
ROSENBERG ML, Jabbari B: Miosis and internal ophthalmoplegia as a manifestation of partial seizures. Neurology 41:737-739, 1991.
ROSENBERG, ML, Kroll, Martin H: Pupillary Hippus: An unrecognized example of biologic chaos. J of Biological System 7:85-94, 1999.
Kerrison, JB, Buchanan, K, ROSENBERG, ML, Clark, R, Andreason,K, Alfaro, DV, Grossniklaus, HE, Kerrigan-Baumrind, LA, Kerrigan, DF, Miller, NR, Quigley, HA: Quantification of optic nerve axon loss associated with a relative afferent pupillary defect in the monkey. Archives of Ophthalmology 119:1333-41, 2001.
ROSENBERG ML: Physiologic anisocoria: A manifestation of a physiologic asymmetry of sympathetic tone. Invest Ophthalmol & Vis Sci 29 (Suppl): 79, 1988.
Sinoff S, ROSENBERG ML: Return of the Behr pupil. Neurology 42(Suppl 3):218, 1992.
ROSENBERG ML: Inter-ocular inhibition of the pupillary light reflex. Invest Ophthalmol & Vis Sci 35(Suppl): 1994
ROSENBERG ML: Paroxysmal pupillary contraction to darkness: A normal response. Invest Ophthalmol & Vis Sci 37(Suppl): 159, 1996.
ROSENBERG ML, Gizzi, M, Clark, RJ: Crossing Fibers in the Chasm and Midbrain: A Physiologic Determination Invest Ophthalmol & Vis Sci 40 (Suppl): 1999 V39(4): 1999
Sobol M, ROSENBERG, ML, Clarke, RJ: Pupillary Light Reflex Changes in Patients with Homonymous Hemianopias from Hemispheric Lesions. Invest Ophthalmol & Vis Sci, Vol 40/4:1999.
ROSENBERG, ML, Clarke, RJ: Evidence in Humans for Two Distinct Cell Groups in the Pretectal Nucleus involved in the papillary light reflex. Invest. Ophthalmol. Vis. Sci. Vol 41: 2000
ROSENBERG, ML, Clarke, RJ: Pupillographic Evaluation in Patients with Pituitary Tumors. Invest. Ophthalmol. Vis. Sci. Vol 44: 2003
Research is currently being done with a grant funded by the Department
of Defense to study the effects of fatigue on pupil function, eye
movements and mental functioning.
