Laboratory Director: Dr. Michael Rosenberg
The Human Systems Laboratory for Neural Dynamics seeks to better define CNS physiology by exploring linkages among different neural systems. Our guiding hypothesis is that human physiological systems are linked by central mechanisms that drive both voluntary (somatic) and involuntary (autonomic nervous system, or ANS) activity. We simultaneously and continuously measure somatic motor and sudomotor activities, pupil size, cardiac and respiratory activity, and cerebral blood flow. By employing novel nonlinear signal processing techniques, we are beginning to define correlations between the somatic and autonomic systems, activities that have traditionally been considered independent. Our goal is to advance neurologic diagnostic capabilities by evaluating not only how each system performs in isolation, but also how interactions among the systems are affected by neurologic disease states. Specifically, we are interested in evaluation alterations in central nervous system control over a broad spectrum of neurological conditions, including degenerative processes such as Parkinson’s disease, congenital disorders including autism and attention deficit disorder, as well as acquired abnormalities such as traumatic brain injury, hydrocephalus and various sleep disorders. We are confident that this novel, comprehensive approach to neurologic evaluation will result in more highly focused and effective treatments. Additional areas of interest include using ANS and papillary measurements to obtain objective assessments of consciousness at the bedside in minimally conscious patients, and the application of new nonlinear mathematical tools to other physiological and pathophysiological systems.